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dc.contributor.authorNoháčová, Lucie
dc.contributor.authorŽák, František
dc.contributor.authorHulec, Martin
dc.contributor.authorBělík, Milan
dc.contributor.authorOlkhovskiy, Mikhail
dc.date.accessioned2019-11-11T11:00:22Z-
dc.date.available2019-11-11T11:00:22Z-
dc.date.issued2019
dc.identifier.citationPTÁKOVÁ, N., MIESBAUEROVÁ, M., KOSŤUN, J., GROSSMANN, P., ŠIDLOVÁ, H., PAVELKA, J., PRESL, J., ALAGHEHBANDAN, R., BOUDA, J., ONDIČ, O. Immunohistochemical and selected genetic reflex testing of all uterine leiomyosarcomas and STUMPs for ALK gene rearrangement may provide an effective screening tool in identifying uterine ALK-rearranged mesenchymal tumors. Virchows Archiv, 2018, roč. 473, č. 5, s. 583-590. ISSN 0945-6317.en
dc.identifier.uri2-s2.0-85052120925
dc.identifier.urihttp://hdl.handle.net/11025/35861
dc.format8 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherSpringeren
dc.relation.ispartofseriesVirchows Archiven
dc.rightsPlný text je přístupný v rámci univerzity přihlášeným uživatelům.cs
dc.rights© Springeren
dc.titleThe influence of load on the transformers on the size of their own lossesen
dc.typečlánekcs
dc.typearticleen
dc.rights.accessrestrictedAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedWe examined the value of targeted molecular screening for the identification of uterine anaplastic lymphoma kinase (ALK)- rearranged mesenchymal tumors, including ALK immunohistochemistry followed by molecular genetic testing, in all uterine leiomyosarcomas and STUMPs (smooth muscle tumors of uncertain malignant potential). All leiomyosarcoma and STUMP cases diagnosed in a 10-year period (2006–2016) at Charles University Faculty of Medicine in Pilsen were retrieved and reviewed. Of 23 cases, one case (LMS [leiomyosarcoma]) was positive for ALK rearrangement, namely, PPP1CB–ALK fusion gene. No specific histologic features (i.e., lymphocytic infiltrate and stromal edema) were observed in this case. This suggests that inflammatory myofibroblastic tumor (IMT)-like histologic features may not be an initial reliable screening tool in identifying uterine IMT cases. Thus, we proposed a two-step IHC and molecular genetic testing (as a reflex test) for IMT in all uterine LMS and STUMP cases. This will enhance the proper detection of such tumors at the population level and ultimately offer patients available targeted therapies.en
dc.subject.translatedtransformers own lossesen
dc.subject.translatedelectrical network operationen
dc.type.statusPeer-revieweden
dc.identifier.obd43926989
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