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dc.contributor.authorRohan, Eduard
dc.contributor.authorCamprová Turjanicová, Jana
dc.contributor.authorLiška, Václav
dc.date.accessioned2022-02-28T11:00:23Z-
dc.date.available2022-02-28T11:00:23Z-
dc.date.issued2021
dc.identifier.citationROHAN, E. CAMPROVÁ TURJANICOVÁ, J. LIŠKA, V. Geometrical model of lobular structure and its importance for the liver perfusion analysis. PLoS One, 2021, roč. 16, č. 12, s. 1-21. ISSN: 1932-6203cs
dc.identifier.issn1932-6203
dc.identifier.uri2-s2.0-85120714787
dc.identifier.urihttp://hdl.handle.net/11025/47018
dc.format21 s.cs
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.ispartofseriesPLoS Oneen
dc.rights© authorsen
dc.titleGeometrical model of lobular structure and its importance for the liver perfusion analysisen
dc.typečlánekcs
dc.typearticleen
dc.rights.accessopenAccessen
dc.type.versionpublishedVersionen
dc.description.abstract-translatedA convenient geometrical description of the microvascular network is necessary for computationally efficient mathematical modelling of liver perfusion, metabolic and other physiological processes. The tissue models currently used are based on the generally accepted schematic structure of the parenchyma at the lobular level, assuming its perfect regular structure and geometrical symmetries. Hepatic lobule, portal lobule, or liver acinus are considered usually as autonomous functional units on which particular physiological problems are studied. We propose a new periodic unit - the liver representative periodic cell (LRPC) and establish its geometrical parametrization. The LRPC is constituted by two portal lobulae, such that it contains the liver acinus as a substructure. As a remarkable advantage over the classical phenomenological modelling approaches, the LRPC enables for multiscale modelling based on the periodic homogenization method. Derived macroscopic equations involve so called effective medium parameters, such as the tissue permeability, which reflect the LRPC geometry. In this way, mutual influences between the macroscopic phenomena, such as inhomogeneous perfusion, and the local processes relevant to the lobular (mesoscopic) level are respected. The LRPC based model is intended for its use within a complete hierarchical model of the whole liver. Using the Double-permeability Darcy model obtained by the homogenization, we illustrate the usefulness of the LRPC based modelling to describe the blood perfusion in the parenchyma.en
dc.subject.translatedgeometrical model, liver tissue, hepatic lobulus, blood microcirculation, multi-scale modellingen
dc.identifier.doi10.1371/journal.pone.0260068
dc.type.statusPeer-revieweden
dc.identifier.document-number735299000028
dc.identifier.obd43934154
dc.project.IDEF17_048/0007280/Aplikace moderních technologií v medicíně a průmyslucs
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